ANGIOFIBROMA NASOFARINGEO PDF

Introduction: Juvenile nasopharyngeal angiofibroma is a rare, highly .. Luiz A CR, Romualdo S LT, Fava A S. Angiofibroma nasofaríngeo: revisão de literatura. Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.

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Endoscopic surgery is less invasive than open surgery, causing less damage to the patient. Computed tomography of a year-old patient with a Fisch class IIIa juvenile nasopharyngeal angiofibroma.

Angiofibroma nasofaríngeo juvenil

At the time of diagnosis, the mass classically involves the pterygopalatine fossa. InFriedberg called it juvenile angiofibroma.

The JNA is a highly vascularized tumor and its probable original site is in the upper margin of the sphenopalatine foramen 1,3. How to cite this article. J Clin Imaging Sci.

Nasopharyngeal angiofibroma – Wikipedia

Pathogenisis of Juvenile Nasopharyngeal Fibroma A new concept. Currently it is believed that the tumor has its origin in the posterolateral wall of the nasal cavity, where the sphenoid process of palatine bone meets the horizontal lamina of the vomer and part of the pterygoid process of sphenoid bone.

Nasal endoscopy, alone or combined with open techniques, was safe for the resection of angiofibromas at different stages, with low morbidity and high efficacy, as shown by complete tumor removal and low recurrence rates.

However, as in any invasive procedure, embolization presents risks that angiofibroam be fully explained to the patients Invasion of the intracranial region may lead to cranial nerve palsy. He also complained of difficulty in breathing since 6—7 months. Therefore there is need for further action to claim that this technique has a low recurrence rate, since the recurrence is probably related to incomplete resection of the initial tumor.

Irradiation may be an option if surgery is not possible or only incomplete resection achieved 2,4,6. Biological distinctions between juvenile nasopharyngeal angiofibroma and nnasofaringeo malformation: Click here for nasoafringeo on linking to our website or using our content or images.

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Tumors that further extend into the infratemporal fossa may progress into the orbit, through the inferior orbital fissure and to the base of angiofibromma skull through the base of the pterygoid process. The genetic alterations observed more often involve sex chromosomes. Ideally, the time between the completion of embolization and the endoscopic procedure should be angiofibromx small as possible, approximately h We analyzed findings in 20 angioribroma who underwent surgery between and Proliferation, angiogenesis and hormonal markers in juvenile nasopharyngeal angiofibroma.

Improvements in surgical techniques are designed to shorten surgical time and thereby reduce patient morbidity. However, the existence of a selectivity pursuant to sex, the spontaneous regression in some few patients and the malign transformation in very rare cases altogether suggest the existence of complex genetic mechanisms in its pathogenesis Juvenile nasopharyngeal angiofibroma and familial adenomatous polyposis: Diagnosis of JNA is made by complete history, clinical examination, radiography, nasal endoscopy and by using specialized imaging techniques such as arteriography, computer tomography and magnetic resonance imaging.

Overlying mucosa appeared normal. Olfactory neuroblastoma Olfactory neuroblastoma. All patients were male, and all had symptoms of progressive nasal obstruction and recurrent epistaxis.

Indian J Dent Res. Similarly, our patients ranged in age from 10 to 29 years, nnasofaringeo a mean age of 16 years, and all were male.

Of our 20 patients, 3 required a combination of endoscopic and open surgery, with one, with a Fisch IIIA tumor, having expanded Caldwell-Luc and endoscopic techniques; one, with a Fisch IIIA tumor, undergoing mid-facial degloving and endoscopic surgery; and one, with a Fisch IVA tumor, having mid-facial degloving, craniotomy, and endoscopic surgery Figure 4. Connective tissue was fibro-cellular with irregular pattern and plump fibroblasts [ Figure 6 ]. Case 7 Case 7.

Received Aug 21; Accepted Oct 7. Hippocrates first described this tumor in the 5 th century B. Mortality is not associated with nasopharyngeal angiofibroma.

Nasopharyngeal Angiofibroma: Review of the Genetic and Molecular Aspects

The excised gross specimen was angiofibroms to firm in consistency, white to yellow with darker vascular areas.

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The combination of different accesses to the tumor can be required 9. As already stated previously, a growth factor that seems to be involved in the JNA pathogenesis is the IGFII, for its significant overexpression in this tumor, along with other factors such as the PDGF platelet derivate growth factor, but without the same expression level Angiofiborma started the first surgical dissection of the tumor through a unciform process incision, anterior and posterior ethmoidectomy with wide exposure of the lamina papyracea and the ethmoid roof.

Vessel density, proliferation, and immunol immunolocalization of vascular endothelial growth factor in juvenile nasopharyngeal angiofbromas. Computed tomography CT scan showed the presence of a soft tissue mass involving the maxillary sinus, nasal cavity, and nasopharynx.

This relatively low blood loss may be due to the use of surgical endoscopy, providing better control of bleeding than open surgery, with angiofkbroma without endoscopy. External carotid clamping has been shown to assist in hemostasis of the tumor. Examinations such as computed tomography, nuclear magnetic resonance and nasofzringeo nasal endoscopy can clearly establish the extent of the tumor, its pattern of spread, and consequently, surgical planning 10 11 12 16 17 18 The hormonal influence in JNA remains controversial.

Intracranial juvenile nasopharyngeal angiofibroma.

These tumors occur almost exclusively in male adolescents and account for 0. Click here for patient related inquiries. Immunolocalization of activated transforming growth factor beta angiofiborma in juvenile nasopharyngeal angiofibroma.

Nasopharyngeal angiofibroma

The recurrence rate of endoscopically resected tumors has been shown to be low, and we found that none of our 20 patients experienced tumor recurrence. The changes quantity in number of copies is higher then that of several malign tumors, despite the JNA is histologically seen as a benign tumor.

Supply of these tumours is usually via